We seek to characterize drivers of Uropathogenic E. Coli (UPEC) epidemiology in northwestern Ecuador. Specifically, we aim to quantify the percent of human UPEC infection that come from chicken compared to humans, and assess the behaviors and environmental conditions associated with risk for colonization and infection. We will carry out active surveillance at regional hospitals and follow 420 households prospectively. We hypothesize that poultry will be an important source of UPEC infection in humans